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Vaccinia Virus (VACV) Service- Global Market Share and Ranking, Overall Sales and Demand Forecast 2024-2030

Industry: Medical Care

Published: 2024-12-14

Pages: 96 Pages

Report ld: 3404030

Description
Table of Contents
Table of Figures
PDF Download

Description
Table of Contents
Table of Figures
PDF Download

Vaccinia virus (VACV or VV) is the most widely used viral vector for the study of exogenous gene expression and immunogenicity of the resulting protein. Replication-competent recombinant VACV-based vaccines have received increasing attention as potential vaccine vectors for many infectious diseases, as they may be able to elicit potent humoral and cell-mediated immune responses and long-lasting protection.Vaccinia virus (VACV) is a large enveloped, double-stranded DNA virus in the genus of Orthopoxvirus of the family Poxviridae. The VACV genome is comprised of approximately 190,000 nucleotides which encodes approximately 250 genes. VACV is one of the most commonly developed oncolytic vectors. There are several features make VACV a promising oncolytic vector which include excellent lytic activity, natural and broad tumor tropism as well as well-known and easy-manipulating genome structure etc.

Table of Contents

 1 Market Overview
    1.1 Vaccinia Virus (VACV) Service Product Introduction
    1.2 Global Vaccinia Virus (VACV) Service Market Size Forecast (2019-2030)
    1.3 Vaccinia Virus (VACV) Service Market Trends & Drivers
        1.3.1 Vaccinia Virus (VACV) Service Industry Trends
        1.3.2 Vaccinia Virus (VACV) Service Market Drivers & Opportunity
        1.3.3 Vaccinia Virus (VACV) Service Market Challenges
        1.3.4 Vaccinia Virus (VACV) Service Market Restraints
    1.4 Assumptions and Limitations
    1.5 Study Objectives
    1.6 Years Considered

 2 Competitive Analysis by Company
    2.1 Global Vaccinia Virus (VACV) Service Players Revenue Ranking (2023)
    2.2 Global Vaccinia Virus (VACV) Service Revenue by Company (2019-2024)
    2.3 Key Companies Vaccinia Virus (VACV) Service Manufacturing Base Distribution and Headquarters
    2.4 Key Companies Vaccinia Virus (VACV) Service Product Offered
    2.5 Key Companies Time to Begin Mass Production of Vaccinia Virus (VACV) Service
    2.6 Vaccinia Virus (VACV) Service Market Competitive Analysis
        2.6.1 Vaccinia Virus (VACV) Service Market Concentration Rate (2019-2024)
        2.6.2 Global 5 and 10 Largest Companies by Vaccinia Virus (VACV) Service Revenue in 2023
        2.6.3 Global Top Companies by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in Vaccinia Virus (VACV) Service as of 2023)
    2.7 Mergers & Acquisitions, Expansion

 3 Segmentation by Type
    3.1 Introduction by Type
        3.1.1 Attenuated Vaccinia Virus
        3.1.2 Recombinant Vaccinia Virus
        3.1.3 Other
    3.2 Global Vaccinia Virus (VACV) Service Sales Value by Type
        3.2.1 Global Vaccinia Virus (VACV) Service Sales Value by Type (2019 VS 2023 VS 2030)
        3.2.2 Global Vaccinia Virus (VACV) Service Sales Value, by Type (2019-2030)
        3.2.3 Global Vaccinia Virus (VACV) Service Sales Value, by Type (%) (2019-2030)

 4 Segmentation by Application
    4.1 Introduction by Application
        4.1.1 Scientific Research
        4.1.2 Vaccine Development
        4.1.3 Oncolytic Therapy
    4.2 Global Vaccinia Virus (VACV) Service Sales Value by Application
        4.2.1 Global Vaccinia Virus (VACV) Service Sales Value by Application (2019 VS 2023 VS 2030)
        4.2.2 Global Vaccinia Virus (VACV) Service Sales Value, by Application (2019-2030)
        4.2.3 Global Vaccinia Virus (VACV) Service Sales Value, by Application (%) (2019-2030)

 5 Segmentation by Region
    5.1 Global Vaccinia Virus (VACV) Service Sales Value by Region
        5.1.1 Global Vaccinia Virus (VACV) Service Sales Value by Region: 2019 VS 2023 VS 2030
        5.1.2 Global Vaccinia Virus (VACV) Service Sales Value by Region (2019-2024)
        5.1.3 Global Vaccinia Virus (VACV) Service Sales Value by Region (2025-2030)
        5.1.4 Global Vaccinia Virus (VACV) Service Sales Value by Region (%), (2019-2030)
    5.2 North America
        5.2.1 North America Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        5.2.2 North America Vaccinia Virus (VACV) Service Sales Value by Country (%), 2023 VS 2030
    5.3 Europe
        5.3.1 Europe Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        5.3.2 Europe Vaccinia Virus (VACV) Service Sales Value by Country (%), 2023 VS 2030
    5.4 Asia Pacific
        5.4.1 Asia Pacific Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        5.4.2 Asia Pacific Vaccinia Virus (VACV) Service Sales Value by Region (%), 2023 VS 2030
    5.5 South America
        5.5.1 South America Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        5.5.2 South America Vaccinia Virus (VACV) Service Sales Value by Country (%), 2023 VS 2030
    5.6 Middle East & Africa
        5.6.1 Middle East & Africa Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        5.6.2 Middle East & Africa Vaccinia Virus (VACV) Service Sales Value by Country (%), 2023 VS 2030

 6 Segmentation by Key Countries/Regions
    6.1 Key Countries/Regions Vaccinia Virus (VACV) Service Sales Value Growth Trends, 2019 VS 2023 VS 2030
    6.2 Key Countries/Regions Vaccinia Virus (VACV) Service Sales Value, 2019-2030
    6.3 United States
        6.3.1 United States Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        6.3.2 United States Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
        6.3.3 United States Vaccinia Virus (VACV) Service Sales Value by Application, 2023 VS 2030
    6.4 Europe
        6.4.1 Europe Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        6.4.2 Europe Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
        6.4.3 Europe Vaccinia Virus (VACV) Service Sales Value by Application, 2023 VS 2030
    6.5 China
        6.5.1 China Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        6.5.2 China Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
        6.5.3 China Vaccinia Virus (VACV) Service Sales Value by Application, 2023 VS 2030
    6.6 Japan
        6.6.1 Japan Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        6.6.2 Japan Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
        6.6.3 Japan Vaccinia Virus (VACV) Service Sales Value by Application, 2023 VS 2030
    6.7 South Korea
        6.7.1 South Korea Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        6.7.2 South Korea Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
        6.7.3 South Korea Vaccinia Virus (VACV) Service Sales Value by Application, 2023 VS 2030
    6.8 Southeast Asia
        6.8.1 Southeast Asia Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        6.8.2 Southeast Asia Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
        6.8.3 Southeast Asia Vaccinia Virus (VACV) Service Sales Value by Application, 2023 VS 2030
    6.9 India
        6.9.1 India Vaccinia Virus (VACV) Service Sales Value, 2019-2030
        6.9.2 India Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
        6.9.3 India Vaccinia Virus (VACV) Service Sales Value by Application, 2023 VS 2030

 7 Company Profiles
    7.1 VectorBuilder
        7.1.1 VectorBuilder Profile
        7.1.2 VectorBuilder Main Business
        7.1.3 VectorBuilder Vaccinia Virus (VACV) Service Products, Services and Solutions
        7.1.4 VectorBuilder Vaccinia Virus (VACV) Service Revenue (US$ Million) & (2019-2024)
        7.1.5 VectorBuilder Recent Developments
    7.2 Creative Biolabs
        7.2.1 Creative Biolabs Profile
        7.2.2 Creative Biolabs Main Business
        7.2.3 Creative Biolabs Vaccinia Virus (VACV) Service Products, Services and Solutions
        7.2.4 Creative Biolabs Vaccinia Virus (VACV) Service Revenue (US$ Million) & (2019-2024)
        7.2.5 Creative Biolabs Recent Developments
    7.3 Creative Biogene
        7.3.1 Creative Biogene Profile
        7.3.2 Creative Biogene Main Business
        7.3.3 Creative Biogene Vaccinia Virus (VACV) Service Products, Services and Solutions
        7.3.4 Creative Biogene Vaccinia Virus (VACV) Service Revenue (US$ Million) & (2019-2024)
        7.3.5 Creative Biogene Recent Developments
    7.4 Genevoyager (Wuhan) Co., Ltd.
        7.4.1 Genevoyager (Wuhan) Co., Ltd. Profile
        7.4.2 Genevoyager (Wuhan) Co., Ltd. Main Business
        7.4.3 Genevoyager (Wuhan) Co., Ltd. Vaccinia Virus (VACV) Service Products, Services and Solutions
        7.4.4 Genevoyager (Wuhan) Co., Ltd. Vaccinia Virus (VACV) Service Revenue (US$ Million) & (2019-2024)
        7.4.5 Genevoyager (Wuhan) Co., Ltd. Recent Developments
    7.5 Esco Aster Pte. Ltd.
        7.5.1 Esco Aster Pte. Ltd. Profile
        7.5.2 Esco Aster Pte. Ltd. Main Business
        7.5.3 Esco Aster Pte. Ltd. Vaccinia Virus (VACV) Service Products, Services and Solutions
        7.5.4 Esco Aster Pte. Ltd. Vaccinia Virus (VACV) Service Revenue (US$ Million) & (2019-2024)
        7.5.5 Esco Aster Pte. Ltd. Recent Developments
    7.6 Sementis
        7.6.1 Sementis Profile
        7.6.2 Sementis Main Business
        7.6.3 Sementis Vaccinia Virus (VACV) Service Products, Services and Solutions
        7.6.4 Sementis Vaccinia Virus (VACV) Service Revenue (US$ Million) & (2019-2024)
        7.6.5 Sementis Recent Developments

 8 Industry Chain Analysis
    8.1 Vaccinia Virus (VACV) Service Industrial Chain
    8.2 Vaccinia Virus (VACV) Service Upstream Analysis
        8.2.1 Key Raw Materials
        8.2.2 Raw Materials Key Suppliers
        8.2.3 Manufacturing Cost Structure
    8.3 Midstream Analysis
    8.4 Downstream Analysis (Customers Analysis)
    8.5 Sales Model and Sales Channels
        8.5.1 Vaccinia Virus (VACV) Service Sales Model
        8.5.2 Sales Channel
        8.5.3 Vaccinia Virus (VACV) Service Distributors

 9 Research Findings and Conclusion

 10 Appendix
    10.1 Research Methodology
        10.1.1 Methodology/Research Approach
            10.1.1.1 Research Programs/Design
            10.1.1.2 Market Size Estimation
            10.1.1.3 Market Breakdown and Data Triangulation
        10.1.2 Data Source
            10.1.2.1 Secondary Sources
            10.1.2.2 Primary Sources
    10.2 Author Details
    10.3 Disclaimer

Table of Figures

List of Tables
 Table 1. Vaccinia Virus (VACV) Service Market Trends
 Table 2. Vaccinia Virus (VACV) Service Market Drivers & Opportunity
 Table 3. Vaccinia Virus (VACV) Service Market Challenges
 Table 4. Vaccinia Virus (VACV) Service Market Restraints
 Table 5. Global Vaccinia Virus (VACV) Service Revenue by Company (2019-2024) & (US$ Million)
 Table 6. Global Vaccinia Virus (VACV) Service Revenue Market Share by Company (2019-2024)
 Table 7. Key Companies Vaccinia Virus (VACV) Service Manufacturing Base Distribution and Headquarters
 Table 8. Key Companies Vaccinia Virus (VACV) Service Product Type
 Table 9. Key Companies Time to Begin Mass Production of Vaccinia Virus (VACV) Service
 Table 10. Global Vaccinia Virus (VACV) Service Companies Market Concentration Ratio (CR5 and HHI)
 Table 11. Global Top Companies Market Share by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in Vaccinia Virus (VACV) Service as of 2023)
 Table 12. Mergers & Acquisitions, Expansion Plans
 Table 13. Global Vaccinia Virus (VACV) Service Sales Value by Type: 2019 VS 2023 VS 2030 (US$ Million)
 Table 14. Global Vaccinia Virus (VACV) Service Sales Value by Type (2019-2024) & (US$ Million)
 Table 15. Global Vaccinia Virus (VACV) Service Sales Value by Type (2025-2030) & (US$ Million)
 Table 16. Global Vaccinia Virus (VACV) Service Sales Market Share in Value by Type (2019-2024)
 Table 17. Global Vaccinia Virus (VACV) Service Sales Market Share in Value by Type (2025-2030)
 Table 18. Global Vaccinia Virus (VACV) Service Sales Value by Application: 2019 VS 2023 VS 2030 (US$ Million)
 Table 19. Global Vaccinia Virus (VACV) Service Sales Value by Application (2019-2024) & (US$ Million)
 Table 20. Global Vaccinia Virus (VACV) Service Sales Value by Application (2025-2030) & (US$ Million)
 Table 21. Global Vaccinia Virus (VACV) Service Sales Market Share in Value by Application (2019-2024)
 Table 22. Global Vaccinia Virus (VACV) Service Sales Market Share in Value by Application (2025-2030)
 Table 23. Global Vaccinia Virus (VACV) Service Sales Value by Region, (2019 VS 2023 VS 2030) & (US$ Million)
 Table 24. Global Vaccinia Virus (VACV) Service Sales Value by Region (2019-2024) & (US$ Million)
 Table 25. Global Vaccinia Virus (VACV) Service Sales Value by Region (2025-2030) & (US$ Million)
 Table 26. Global Vaccinia Virus (VACV) Service Sales Value by Region (2019-2024) & (%)
 Table 27. Global Vaccinia Virus (VACV) Service Sales Value by Region (2025-2030) & (%)
 Table 28. Key Countries/Regions Vaccinia Virus (VACV) Service Sales Value Growth Trends, (US$ Million): 2019 VS 2023 VS 2030
 Table 29. Key Countries/Regions Vaccinia Virus (VACV) Service Sales Value, (2019-2024) & (US$ Million)
 Table 30. Key Countries/Regions Vaccinia Virus (VACV) Service Sales Value, (2025-2030) & (US$ Million)
 Table 31. VectorBuilder Basic Information List
 Table 32. VectorBuilder Description and Business Overview
 Table 33. VectorBuilder Vaccinia Virus (VACV) Service Products, Services and Solutions
 Table 34. Revenue (US$ Million) in Vaccinia Virus (VACV) Service Business of VectorBuilder (2019-2024)
 Table 35. VectorBuilder Recent Developments
 Table 36. Creative Biolabs Basic Information List
 Table 37. Creative Biolabs Description and Business Overview
 Table 38. Creative Biolabs Vaccinia Virus (VACV) Service Products, Services and Solutions
 Table 39. Revenue (US$ Million) in Vaccinia Virus (VACV) Service Business of Creative Biolabs (2019-2024)
 Table 40. Creative Biolabs Recent Developments
 Table 41. Creative Biogene Basic Information List
 Table 42. Creative Biogene Description and Business Overview
 Table 43. Creative Biogene Vaccinia Virus (VACV) Service Products, Services and Solutions
 Table 44. Revenue (US$ Million) in Vaccinia Virus (VACV) Service Business of Creative Biogene (2019-2024)
 Table 45. Creative Biogene Recent Developments
 Table 46. Genevoyager (Wuhan) Co., Ltd. Basic Information List
 Table 47. Genevoyager (Wuhan) Co., Ltd. Description and Business Overview
 Table 48. Genevoyager (Wuhan) Co., Ltd. Vaccinia Virus (VACV) Service Products, Services and Solutions
 Table 49. Revenue (US$ Million) in Vaccinia Virus (VACV) Service Business of Genevoyager (Wuhan) Co., Ltd. (2019-2024)
 Table 50. Genevoyager (Wuhan) Co., Ltd. Recent Developments
 Table 51. Esco Aster Pte. Ltd. Basic Information List
 Table 52. Esco Aster Pte. Ltd. Description and Business Overview
 Table 53. Esco Aster Pte. Ltd. Vaccinia Virus (VACV) Service Products, Services and Solutions
 Table 54. Revenue (US$ Million) in Vaccinia Virus (VACV) Service Business of Esco Aster Pte. Ltd. (2019-2024)
 Table 55. Esco Aster Pte. Ltd. Recent Developments
 Table 56. Sementis Basic Information List
 Table 57. Sementis Description and Business Overview
 Table 58. Sementis Vaccinia Virus (VACV) Service Products, Services and Solutions
 Table 59. Revenue (US$ Million) in Vaccinia Virus (VACV) Service Business of Sementis (2019-2024)
 Table 60. Sementis Recent Developments
 Table 61. Key Raw Materials Lists
 Table 62. Raw Materials Key Suppliers Lists
 Table 63. Vaccinia Virus (VACV) Service Downstream Customers
 Table 64. Vaccinia Virus (VACV) Service Distributors List
 Table 65. Research Programs/Design for This Report
 Table 66. Key Data Information from Secondary Sources
 Table 67. Key Data Information from Primary Sources
 Table 68. Business Unit and Senior & Team Lead Analysts


List of Figures
 Figure 1. Vaccinia Virus (VACV) Service Product Picture
 Figure 2. Global Vaccinia Virus (VACV) Service Sales Value, 2019 VS 2023 VS 2030 (US$ Million)
 Figure 3. Global Vaccinia Virus (VACV) Service Sales Value (2019-2030) & (US$ Million)
 Figure 4. Vaccinia Virus (VACV) Service Report Years Considered
 Figure 5. Global Vaccinia Virus (VACV) Service Players Revenue Ranking (2023) & (US$ Million)
 Figure 6. The 5 and 10 Largest Companies in the World: Market Share by Vaccinia Virus (VACV) Service Revenue in 2023
 Figure 7. Vaccinia Virus (VACV) Service Market Share by Company Type (Tier 1, Tier 2, and Tier 3): 2019 VS 2023
 Figure 8. Attenuated Vaccinia Virus Picture
 Figure 9. Recombinant Vaccinia Virus Picture
 Figure 10. Other Picture
 Figure 11. Global Vaccinia Virus (VACV) Service Sales Value by Type (2019 VS 2023 VS 2030) & (US$ Million)
 Figure 12. Global Vaccinia Virus (VACV) Service Sales Value Market Share by Type, 2023 & 2030
 Figure 13. Product Picture of Scientific Research
 Figure 14. Product Picture of Vaccine Development
 Figure 15. Product Picture of Oncolytic Therapy
 Figure 16. Global Vaccinia Virus (VACV) Service Sales Value by Application (2019 VS 2023 VS 2030) & (US$ Million)
 Figure 17. Global Vaccinia Virus (VACV) Service Sales Value Market Share by Application, 2023 & 2030
 Figure 18. North America Vaccinia Virus (VACV) Service Sales Value (2019-2030) & (US$ Million)
 Figure 19. North America Vaccinia Virus (VACV) Service Sales Value by Country (%), 2023 VS 2030
 Figure 20. Europe Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 21. Europe Vaccinia Virus (VACV) Service Sales Value by Country (%), 2023 VS 2030
 Figure 22. Asia Pacific Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 23. Asia Pacific Vaccinia Virus (VACV) Service Sales Value by Region (%), 2023 VS 2030
 Figure 24. South America Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 25. South America Vaccinia Virus (VACV) Service Sales Value by Country (%), 2023 VS 2030
 Figure 26. Middle East & Africa Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 27. Middle East & Africa Vaccinia Virus (VACV) Service Sales Value by Country (%), 2023 VS 2030
 Figure 28. Key Countries/Regions Vaccinia Virus (VACV) Service Sales Value (%), (2019-2030)
 Figure 29. United States Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 30. United States Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
 Figure 31. United States Vaccinia Virus (VACV) Service Sales Value by Application (%), 2023 VS 2030
 Figure 32. Europe Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 33. Europe Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
 Figure 34. Europe Vaccinia Virus (VACV) Service Sales Value by Application (%), 2023 VS 2030
 Figure 35. China Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 36. China Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
 Figure 37. China Vaccinia Virus (VACV) Service Sales Value by Application (%), 2023 VS 2030
 Figure 38. Japan Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 39. Japan Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
 Figure 40. Japan Vaccinia Virus (VACV) Service Sales Value by Application (%), 2023 VS 2030
 Figure 41. South Korea Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 42. South Korea Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
 Figure 43. South Korea Vaccinia Virus (VACV) Service Sales Value by Application (%), 2023 VS 2030
 Figure 44. Southeast Asia Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 45. Southeast Asia Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
 Figure 46. Southeast Asia Vaccinia Virus (VACV) Service Sales Value by Application (%), 2023 VS 2030
 Figure 47. India Vaccinia Virus (VACV) Service Sales Value, (2019-2030) & (US$ Million)
 Figure 48. India Vaccinia Virus (VACV) Service Sales Value by Type (%), 2023 VS 2030
 Figure 49. India Vaccinia Virus (VACV) Service Sales Value by Application (%), 2023 VS 2030
 Figure 50. Vaccinia Virus (VACV) Service Industrial Chain
 Figure 51. Vaccinia Virus (VACV) Service Manufacturing Cost Structure
 Figure 52. Channels of Distribution (Direct Sales, and Distribution)
 Figure 53. Bottom-up and Top-down Approaches for This Report
 Figure 54. Data Triangulation
 Figure 55. Key Executives Interviewed

Vaccinia virus (VACV or VV) is the most widely used viral vector for the study of exogenous gene expression and immunogenicity of the resulting protein. Replication-competent recombinant VACV-based vaccines have received increasing attention as potential vaccine vectors for many infectious diseases, as they may be able to elicit potent humoral and cell-mediated immune responses and long-lasting protection.Vaccinia virus (VACV) is a large enveloped, double-stranded DNA virus in the genus of Orthopoxvirus of the family Poxviridae. The VACV genome is comprised of approximately 190,000 nucleotides which encodes approximately 250 genes. VACV is one of the most commonly developed oncolytic vectors. There are several features make VACV a promising oncolytic vector which include excellent lytic activity, natural and broad tumor tropism as well as well-known and easy-manipulating genome structure etc.